Little Sister Savior

The player has completed the game without harvesting any Little Sisters

Dealt with every Little Sister

The player has either Harvested or Rescued every possible Little Sister

Avid Inventor

Successfully invent at least 100 items

Weapon Specialist

Acquire all upgrades for all weapons

Five Fully Upgraded Weapons

Fully upgrade five weapons

Found Cohen's Room

The player has entered Sander Cohen's personal quarters

Irony

The player has taken a picture of Sander Cohen's corpse

Research PhD

Max out all possible research

Fully Researched Nitro Splicer

Fully research the Nitro Splicer

Maxed All Tracks

Purchased every slot in all four Plasmid and Tonic tracks

Fully Researched Little Sister

Fully research the Little Sister

Fully Researched Bouncer

Fully research the Bouncer

Lucky Winner

Hit the jackpot at a slot machine

Fully Researched Spider Splicer

The player has fully researched the Spider Splicer

Fully Researched Rosie

Fully research the Rosie

Fully Researched Houdini Splicer

Fully research the Houdini Splicer

Fully Researched Thug Splicer

The player has fully researched the Thuggish Splicer

Skilled Hacker

The player has successfully completed 50 hacks

Fully Researched Gun Splicer

The player has fully researched the Leadhead Splicer

Hacked a Turret

The player has successfully hacked a turret

Defeated Atlas

The player has defeated Atlas

Became a Big Daddy

The player has become a Big Daddy

Four Fully Upgraded Weapons

Fully upgrade four weapons

Broke Fontaine's Mind Control

The player has broken Fontaine's mind control

Prolific Photographer

Take at least one photo in every research group

Defeated Andrew Ryan

The player has defeated Andrew Ryan

Ammo Inventor

The player has successfully invented all possible ammo types

Three Fully Upgraded Weapons

The player has fully upgraded three weapons

Completed Cohen's Masterpiece

The player has completed Sander Cohen's great masterpiece

Two Fully Upgraded Weapons

The player has fully upgraded two weapons

Restored the Forest

The player has restored the forests of Arcadia

One Fully Upgraded Weapon

The player has fully upgraded one weapon

Maxed One Track

The player has purchased every slot in one of the Plasmid or Tonic tracks

Hacked a Security Camera

The player has successfully hacked a security camera

Basic Inventor

The player has successfully invented at least one item

Quality Research Photo

The player has taken a Research Photo of the highest grade

Upgraded a Weapon

The player has acquired at least one weapon upgrade

Defeated Peach Wilkins

The player has defeated Peach Wilkins

Researched a Splicer

The player has taken at least one Research Photo of a Splicer

Bought One Slot

The player has purchased one slot in any Plasmid or Tonic track

Defeated Dr. Steinman

The player has defeated the crazed Dr. Steinman

Hacked a Safe

The player has successfully hacked a safe

Hacked a Vending Machine

The player has successfully hacked a vending machine

Hacked a Security Bot

The player has successfully hacked a security bot

One Successful Hack

The player has performed at least one successful hack

Completed Welcome

The player has successfully completed the Welcome To Rapture Level

Toaster in the Tub

The player has shocked an enemy in the water